On the tubulin polymerization promoting proteins of zebrafish
نویسندگان
چکیده
منابع مشابه
On the tubulin polymerization promoting proteins of zebrafish.
Recently, Aoki et al. [15] have been published a paper (Biochem. Biophys. Res. Commun. 445 (2014) 357-362.) in which they identified possible downstream genes required for the extension of peripheral axons in primary sensory neurons of zebrafish. Tppp was claimed as one of them but, as I show, it is the tppp3-like gene, a paralog of tppp, which plays this role. There are three tppp paralogs in ...
متن کاملTubulin polymerization promoting protein 1 (TPPP1)
The eukaryotic cell cycle relies heavily on the mechanical forces vested by the dynamic rearrangement of the microtubule (MT) network. Tubulin Polymerization promoting Protein 1 (TPPP1) alters MT dynamics by driving MT polymerization as well as stabilization, via increasing MT acetylation. It increases MT rigidity, which results in reduced cell proliferation through downregulation of G1/S-phase...
متن کاملBrain tubulin polymerization in the absence of "microtubule-associated proteins".
Pure tubulin dimer, purified by phosphecellulose chromatography to remove microtubule associated proteins, can be assembled into microtubules in the presence of dimethyl sulfoxide. The surfaces of such microtubules are devoid of filamentous material. The reaction is rapid and strongly dependent on protein concentration. No microtubule formation occurs from the purified tubulin when dimethyl sul...
متن کاملIntrinsic calcium sensitivity of tubulin polymerization. The contributions of temperature, tubulin concentration, and associated proteins.
The calcium concentration required to inhibit tubulin polymerization by 50% (Ca2+ sensitivity) extends from the micromolar to the millimolar range and is a function of a number of factors that include 1) a steep, inverse dependence on tubulin concentration: two-cycle tubulin has lower Ca2+ sensitivity than pure tubulin (prepared by a novel method described under "Appendix"); 2) temperature: Ca2...
متن کاملProteins from morphologically differentiated neuroblastoma cells promote tubulin polymerization
Clonal cells (N18) of the mouse neuroblastoma C-1300 can be induced to undergo a morphological differentiation characterized by the outgrowth of very long neurites (> 150 microns) that contain many microtubules. Because the marked increase in the number and length of microtubules is apparently not due to an increase in the concentration of tubulin subunits, the possible role of additional macro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2015
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2014.12.099